Alzheimer's- Borrelia Infections

$19,600 of $20k goal

Raised by 195 people in 20 months
Alan MacDonald  NAPLES, FL

Alzheimer's Disease
Studied with Autopsy
demonstrates  that Infection by Borrelia Spirochetes
is regularly present in Autopsy Alzheimer's Disease
brains. The Chronic Borrelia Brain Infection is
a Cause of Alzheimer's Disease.

The Model  for  Dementia CAUSED by Chronic
 brain Infections by Spirochetes is the
 conclusive Model of Dr. Hideyo Noguchi
 who proved that Treponema Pallidum
 late chronic Brain Infection is
 THE CAUSE  of General Paresis [ Syphilis dementia]

21st century tools investigate infection by detection of
microbe's DNA at the site of the Disease
in human tissue.

DNA of Borrelia is Present in the following
                          areas of the Alzheimer's Brain:
1.  All of the Alzheimer's Plaques
2.  Perfect Spirochetes (Borrelia) are seen
       under the fluorescent microscope
       in solid brain tissues, in Blood vessels
       of the Brain, and in the Alzheimer's Plaques.
3.  All of the Granular bodies which are present
        in dying nerve cells in the Alzheimer's Brain
        (Granulo-vacuolar Degeneration: {GVB Lesions]
Autopsy Brain, when placed in Laboratory Cultures
         produce pure Cultures of Borrelia spirochetes.

My present Research uses DNA Probes , specific for borrelia , to bind to  sites in diseased brain tissues, 
specifically Alzheimer's Disease Autopsy Brain tissues.

FISH methods (Fluorescence In Situ DNA Hybridization)-  in my research -  utilizes the
BEST DNA PROBES available today, specifically
Molecular Beacons.  The Molecular Beacons
absolutely bind to Target Borrelia DNA ...
but only will bind to a DNA ..
if There is a 100% match-
between TheMicrobe Borrelia DNA in diseased tissues - and the DNA structure in My  Molecular Beacon DNA Probes...
            If even a single Base (nucleotide "A"or"T" ,or"G", or "C") Mismatch exists, ..
the 100% rule for Molecular Beacon Binding is Violated,.
and no signal will be released by the DNA probe.  A positive signal indicates that the 100% match rule for Molecular Beacon DNA Probe binding has been satisfied.  A Positive FISH Hybridization in
Alzheimer's Brain,  is bulletproof evidence of Borrelia
infection - Visualized by the Fluorescent Microscope.
FISH Borrelia Probes Visualize ENTIRE Borrelia
spirochetes - at the EXACT sites of Alzheimer's tissue
injuries..

In a Series of  
cases from the Harvard Brain Bank ,

         [from Alzheimer's Disease Brains]..
my Molecular Beacon DNA Probes bound to Borrelia DNA in ALL CASES STUDIED. (5/5)

The astonishing observation in my DNA probe studies on the Harvard Brain Bank Alzheimer's Disease Cases is the Discovery of not just One Borrelia,  But, Two strains of borrelia in five of five Alzheimer' s brains...
Two different   species of Borrelia spirochetes
(Burgdorferi and Miyamotoi)  were simultaneously present in the Alzheimer's Brain tissues, from Harvard.

The Discovery of Burgdorferi  in Alzheimer's Brain
was FIRST published by me in the Journal of the American Medical Association in 1986.  I demonstrated
Borrelia spirochetes from 4 cases obtained from Dr. George Glenner's Brain Bank at the UCSD SanDiego.
I succeeded in a total of 6 Alzheimer's Cases in the culture in the laboratory of Living Borrelia spirochetes
from DEAD (Autopsy Brain) tissue., between 1986 to 1988. Subsequently, in year 1993,  Cultures for borrelia from Autopsy Alzheimer's disease  was again verified by Dr. Judith Miklossy, in Switzerland.

In year 2015, my research continues, with DNA probes
specific for Borrelia DNa in Alzheimer's tissue. I request your support to extend my DNA Probe studies
to connect Chronic Deep Brain Infection with Borrelia
Burgdorferi and Borrelia Miyamotoi in Alzheimer's patients. I want to extend my research to study the
Spinal fluid from living Donor patients with Dementia
to detect Borrelia DNA in the spinal Fluid.

Early Detection of Borrelia Brain Infection offers the opportunity for the patient to be treated in the hope that ERADICATION of Brain and Spinal Fluid Infection, can Prevent the Development of Dementia.

Link: To Teaching Image Galleries:
        Biofilms of borrelia : What do they look like ?
       https://cloud.gonitro.com/p/nGPBFlpKrlddSGJWyQP1hC


I thank you for your support.  All of my research has always been FREE for All , and will remain Free for All.
None of my discoveries have been or ever will be patented .  No patient / volunteer will ever be charged for my research on their Behalf.

Respectfully submitted,

Alan B. MacDonald,MD
Fellow, College of American  Pathologists

8427 Benelli Court
Naples. Florida, 34114, USA


Note: Additional Video Lectures on my Alzheimer's Research  are FREEly available on You Tube and Vimeo.

My Website:
www.alzheimerborreliosis.net

Vimeo Lecture:
Link: https://vimeo.com/140175819

Notes on The Complicated Genetics of Early Onset Alzheimer's Disease:


--
I have examined normal autopsy brains and found them to be free
of  the Biofilm/amyloid plaques  that I imaged in The 100 Alzheimer's plaques.

There is no dispute from me about the Multiple genetic underpinnings that have been linked to Early onset Alzheimer's.
However,  the Genetics are NOT INFORMATIVE about the structure of Amyloid plaques, the reason for small amyloid plaques to grow in size over time to large caliber and high density plaques. the reason for the holes in these plaques, the development of neurofibrillary tangles inside of certain neurons but sparing adjacent neurons completely,and the reason for granular/vacuolar change in other neurons [ also labelled for death= these never containing the Tangles of the NFT neurons.
A reconciliation of Genetic observations in less than 5% of the total number of Alzheimer's Cases, and the ever increasing number of distinctly different mutations, some of which have no "flow chart" to connect a site of mutation with the subsequent evolution of Alzheimer's lead me to believe that  Genetic ideas are not coherent, not the  same from Early AD case to other AD cases, and may constitute " NOISE" at the genetic level..

Further, I  have described Borrelia DNa insertions into the human chromosome 11q and have deposited these PCR sequences in the National GenBank ;[ Search Terms:

" "Transfection DNA"  "MacDonald" "2006".

There are events of genetic mischief induced by borrelia which penetrates human neurons and which gains access to the Human DNa INSIDE of the healthy nucleus.  I believe that the DNA structure of Borrelia DNA ( which resembles the configuration of human DNa more closely than any other infectious microbial DNa- allow for this to happen naturally in the wild.
For those souls who realize that incubations of infectomes residing Inside of human cells for the lifetime of the patient, and for those who understand the delayed onset of tissue pathology, consequent to these Infectomes,  it is an open question as follows:

Can Long incubation times [ of up to 40yrs, 50yrs, 80 yrs..] play a role in the evolution of Borrelia dementias?

Can infection acquired by the unborn fetus while in utero, and then born alive, with normal appearing human development,  in the course of life, develop activation of the Trans placental acquired infection as an mature adult? Tardive  is a word  familiar to those who know the syphilis story. Tardive illness only  appear, years to decades after the penetration of the infecting spirochete into the human body,[ to hide quietly and unobtrusively in  sanctuary sites,[ brain and spinal cord and gonad : all sites of sanctuary for borrelia] ??

Unanswered questions. Questions never queried by the Alzheimer's disease Establishment....Questions which can be answered in part by microscopic study using DNA probes for the infectome DNA/mRNA in tissue biopsies and in body fluids.
I shall attempt to answer the questions.
____________

I have posted Images /Galleries of Borrelia spirochetes under Fluorescent Microscopy  using my FISH method and my Borrelia Specific DNA Probes:
[See Harvard Brain Bank folio below]_____

Resume (Curriculum Vitae) Alan B.MacDonald,MD

Link:
https://www.dropbox.com/s/bz8aplb8l49z7vg/Curriculum%20vitae%20Alan%20B%20MacDonald%20MD%20Sept%201%2C%202015%20PDF.pdf?dl=0

Images of Borrelia Spirochetes in Alzheimer's Autopsy Brain: [Harvard Brain Bank Specimens- an Image Gallery]
Link:
https://www.dropbox.com/s/rlxv1ibmi5jrwf7/Borrelia%20Image%20Gallery%20from%20Alzheimer%27s%20brain%20DNA%20probes%20Hippocampus%20from%20Harvard%20Brain%20Bank.pdf?dl=0

Research Proposal - [ Adopted] to the Board of Directors : Tick Borne Disease Alliance
Link:
https://www.dropbox.com/s/nit8i9k7pygzgo4/PDF-of-Presentation-to-the-Board-of-the-TBDA-October-2012-by-Alan-B.-MacDonald-MD-.pdf?dl=0


Inside of the Alzheimer' Plaque; Borrelia in biofilm:
    100 separate Image Studies with FISH Method
     and Miyamotoi borrelia ( Fla B) DNA probe -Cy5 label- Biofilms of Borrelia:  Image Gallery  from
         Laboratory reared borrelia Bioflms - for comparison    with   In Vivo Borrelia Biofilms  dwelling INSIDE  of  Amyloid Plaques of Alzheimer's  Disease , 
              Visualized by DNA Probe Hybridizations
              in Autopsy tissue sections

Link:
https://cloud.gonitro.com/p/nGPBFlpKrlddSGJWyQP1hC

Dr. Jennifer Souders'  letter -Evaluating the scientific method and the principles utilized in this Research:
Link:
https://www.dropbox.com/s/tjgrlfyxg4kg8e6/Validation%20BeaconDNA.pdf?dl=0

Alan B. MacDonald MD: Lyme Expert Interview Transcripts : Year 2013
Link:

https://files.acrobat.com/a/preview/bd95564d-6adf-4266-a40a-a23fdfbc8872




+ Read More
Update 70
Posted by Alan MacDonald MD
13 months ago
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4
4
Diversity of Forms- All Legitimate- All Borrelia forms
and few to NONE are Corkscrew in form.
DNA probe imaging results - produce images of Borrelia in Diseased tissues- Identical Borrelia Images in Diseased tissues are produced with specific anti-borrelia staining techniques 9 Immuno-Histochemistry (IHC method) , and all of
these Non-Spiral forms are what actually appear in borrelia infected tissues.
The Smallest forms - "Dot Like" ( Granular Borrelia) contain All of the INVECTIVE borrelia DNA needed to cause disease in the human host.
Granular Borrelia ( Dot-like) are the ONLY Borrelia living form which is present in the Bio-films of borrelia
in Alzheimer's Disease tissues- where the Biofilm borrelia communities are discovered beneath EACH and EVERY Amyloid Alzheimer's Plaque in autopsy Brain studies. Dr. Rudolph Tanzi discovered in year 2010, by extraction of Amyloid from Autopsy Alzheimer's Brains, that the purified Alz. Dis. Amyloid
was ANTIBACTERIAL, and that the Amyloid in Alzheimer's Disease is NON_TOXIC.
In my biofilm Model, Each and every Amyloid Plaque in Every Alzheimer's brain - actually is doing its antibacterial job, by Coating the surfaces of the Biofilm communities of borrelia which lie beneath it.
Link to lecture:
https://vimeo.com/140175819

Respectfully,
Alan B. MacDonald, MD
Fellow, College of American Pathologists
February 14, 2106
Biofilms of Borrelia inAlzheimer Plaques
Borrelia in Mammalian Tissue by Antibody
Legitimate Spirochetal Profiles inTissue
+ Read More
Update 69
Posted by Alan MacDonald MD
13 months ago
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1
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Recent Research:

Posters - Seven - Describing Research Results

Link:
http://f1000research.com/search?q=alan%20macdonald&selectedDomain=posters
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Update 68
Posted by Alan MacDonald MD
16 months ago
   Share
2
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Update Nov 7 2015

MacDonald DNA probes used in Autopsy of young child
who died at age 19 months from Disseminated Lymbe borreliosis

Link to full Report: ( coded for patient anonymity)

https://www.dropbox.com/s/xzqqzvk47sr7fpt/SK%20Autopsy%20Brain%20and%20Heart%20with%20Beacons%20for%20B%20Burgdorferi.pdf?dl=0

Respectfully,
Alan B. MacDonald, MD
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Update 67
Posted by Alan MacDonald MD
16 months ago
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1
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Update:

Lyme as a word which induces disbelief/
Borreliosis as a word which stimulates improved
patient care.
Link:
https://www.youtube.com/watch?v=eF1jCOUUsTI
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Read a Previous Update
Alan MacDonald
20 months ago
5
5

Posting Images later today July 12,2015 to illustrate the FISH DNAProbe pictures of Borrelia spirochetes ( Miyamotoi and burgdorferi species) recovered from microscopic exams of Alzheimer's Brain tissues.

+ Read More
Kimberly Kordela
20 months ago
4
4

FUNDRAISER for LYME RESEARCH ♡......(near and dear to my heart). I will donate my entire 30% Ava Anderson Non-Toxic commission to Dr. MacDonald. Must place order here using party #78050: www.NonToxicChick.com I will periodically send in payments to his gofundme page. Email me with questions: KimKordela@gmail.com

+ Read More
Jenifer Koehn Funk
9 months ago

Thank you, Dr. MacDonald for your passionate research. As a Lyme and Babesia sufferer, I thank you for your dedication and pray you will continue to shine your light of discovery on the insidiousness of Lyme for years to come.

+ Read More
Ben A. Sutter Dmd
12 months ago

Alan, very much a fan of your research and Miklossy's. I am a general Dentist that screens patients oral biofilms. I would like to talk shop with you if you have free time. Please contact me on Facebook. Thank you for your work and dedication in this area of science,

+ Read More
April Nill Boitano
17 months ago

You are a genuis! These results are astounding! We, the families affected by Alzheimer's Borelliosis salute you with love and reverence for your intelligence, creativity and tenacity! Soldier on with the blessings and protection of the Lord, we stand behind you Mr. Maverick Pathologist!

+ Read More
Nancy Bowman Kelley
17 months ago

but will the corrupt powers that be even publish his results?. We all know how they pick and choose whatever is most advantageous to repeating the same tired old mantras about borrelia and spirochetes. They are too invested in being right to allow new research disputing their protocols.

+ Read More

$19,600 of $20k goal

Raised by 195 people in 20 months
Created July 11, 2015
BK
$50
Brooke Kramer
3 months ago

Is there a way to donate spinal fluid right now? I got bit in 2013 and I have MCI symptoms.

$5
Anonymous
3 months ago(Monthly Donation)
$100
Michele Miller
4 months ago

Keep up the great work Dr. Alan McDonald! The Central Mass Lyme Foundation supports you!

$5
Anonymous
4 months ago(Monthly Donation)
DH
$100
Deb Hayden
5 months ago

So glad you are continuing your research. Dr. Stokes would approve. :-)

$5
Anonymous
5 months ago(Monthly Donation)
$5
Anonymous
6 months ago(Monthly Donation)
LB
$50
Lori Bowman
6 months ago
SD
$100
Stella Deluca
6 months ago
$100
Anonymous
7 months ago
Alan MacDonald
20 months ago
5
5

Posting Images later today July 12,2015 to illustrate the FISH DNAProbe pictures of Borrelia spirochetes ( Miyamotoi and burgdorferi species) recovered from microscopic exams of Alzheimer's Brain tissues.

+ Read More
Kimberly Kordela
20 months ago
4
4

FUNDRAISER for LYME RESEARCH ♡......(near and dear to my heart). I will donate my entire 30% Ava Anderson Non-Toxic commission to Dr. MacDonald. Must place order here using party #78050: www.NonToxicChick.com I will periodically send in payments to his gofundme page. Email me with questions: KimKordela@gmail.com

+ Read More
Jenifer Koehn Funk
9 months ago

Thank you, Dr. MacDonald for your passionate research. As a Lyme and Babesia sufferer, I thank you for your dedication and pray you will continue to shine your light of discovery on the insidiousness of Lyme for years to come.

+ Read More
Ben A. Sutter Dmd
12 months ago

Alan, very much a fan of your research and Miklossy's. I am a general Dentist that screens patients oral biofilms. I would like to talk shop with you if you have free time. Please contact me on Facebook. Thank you for your work and dedication in this area of science,

+ Read More
April Nill Boitano
17 months ago

You are a genuis! These results are astounding! We, the families affected by Alzheimer's Borelliosis salute you with love and reverence for your intelligence, creativity and tenacity! Soldier on with the blessings and protection of the Lord, we stand behind you Mr. Maverick Pathologist!

+ Read More
Nancy Bowman Kelley
17 months ago

but will the corrupt powers that be even publish his results?. We all know how they pick and choose whatever is most advantageous to repeating the same tired old mantras about borrelia and spirochetes. They are too invested in being right to allow new research disputing their protocols.

+ Read More
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