Research on Hormone Signatures of Women in Ketosis

We are raising funds to investigate female hormone signatures in different metabolic states.

This study aims to investigate the unique hormone signatures of women in long-standing ketosis, focusing on understanding how this metabolic state impacts female-specific hormone panels such as oestrogen, progesterone, testosterone, luteinising hormone and follicle-stimulating hormone as well as insulin and IGF-1, in both healthy individuals and those with metabolic dysfunction and hyperinsulinaemia, a condition closely linked to metabolic disorders. By exploring this novel research area, we aim to establish foundational knowledge that will contribute to the biological and biochemical understanding of women’s health and empower individualised healthcare strategies, guiding orthomolecular and nutritional interventions for metabolic disease in women.

Women face distinct challenges related to hormone balance, including conditions like polycystic ovarian syndrome (PCOS), endometriosis, breast, uterine and ovarian cancer, and infertility. Insulin is a master regulatory hormone that influences growth hormones associated with cancer, inflammatory signalling and regulation of sex hormones, as well as weight gain or unhealthy fatty deposits around the organs. More and more women are implementing lifestyle changes such as fasting and carbohydrate restriction which results in the lowering of insulin and the metabolic state of ketosis which come with improvements in a myriad of biomarkers associated with longevity [1, 2, 3]. However, comprehensive studies of the effects of sustained long-term ketosis on female hormones remain understudied. Our previous research has shown a ketogenic lifestyle improves insulin sensitivity and metabolic markers associated with chronic diseases such as cancer, Alzheimers, cardiovascular disease and ageing, but its specific impact on female hormones in healthy and hyperinsulinaemic populations is poorly understood. Establishing hormonal profiles in long-standing ketosis and in hyperinsulinaemia will provide critical reference data for medical professionals and researchers.

Our study addresses an urgent need for women's health research in metabolic states such as being in long term ketosis versus not in ketosis as well as endocrinology, which aims to:

Forever Young Group is committed to understanding some of the most pressing health challenges facing the world today including cancer, neurological disease, cardiovascular disease and liver disease. We aim to understand the immunological and metabolic mechanisms that underpin these diseases, with the goal of extending health-span and longevity.

100% of your donations will go directly towards funding our research.

If you would like to donate to our research, please donate via our GoFundMe page or visit our website:

foreveryounggroup.com/projects

1. Cooper, I.D.; Kyriakidou, Y.; Edwards, K.; Petagine, L.; Seyfried, T.N.; Duraj, T.; Soto-Mota, A.; Scarborough, A.; Jacome, S.L.; Brookler, K.; et al. Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females. Int. J. Mol. Sci. 2023, 24, 15621.

2. Cooper, I.D.; Kyriakidou, Y.; Petagine, L.; Edwards, K.; Soto-Mota, A.; Brookler, K.; Elliott, B.T. Ketosis Suppression and Ageing (KetoSAge) Part 2: The Effect of Suppressing Ketosis on Biomarkers Associated with Ageing, HOMA-IR, Leptin, Osteocalcin, and GLP-1, in Healthy Females. Biomedicines 2024, 12, 1553.

3. Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards K, Petagine L, Elliot BT and Soto-Mota A (2023) Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model. Front. Endocrinol. 14:1326768.