Fund the folate trial for recurrent miscarriage

Carolyn Ledowsky is a PhD candidate at the University of Technology Sydney and is conducting a pilot study that will inform a larger clinical trial for couples with recurrent miscarriages.

  • Ethics approval Number: ETH22-7218
  • ACTRN12622001577707
We are currently recruiting participants - if you are interested in participating please take our quick questionnaire to see if you qualify
Not all Folate is the same
Folic acid has traditionally been used in prenatal supplements; however, research has identified that other more active forms of folate (methyl folate) may reduce the risk of miscarriage.
Who can this help?
This trial builds on previous research, which identifies that some people may require different folate than folic acid to support a successful pregnancy and prevent miscarriage. By better understanding the role of different Folates during pregnancy, we can better help those going through infertility and miscarriage.
What is the trial about?
We are inviting 60 couples with a history of miscarriage to join the pilot. They will then randomly be assigned to one of two groups:
a) Group that receives folic acid-based prenatal
b) Group that receives methyl folate based prenatal
The couples will take the prenatal product for a minimum of 9 months.
At the end of the pilot study, we will review all elements of the trial to gauge the feasibility of doing a more extensive study with many more people.
We are talking about pregnancy; why do we need men as well?
Prenatal care for men is just as crucial to the conception and fertility process as for women, so this trial will include both men and women.
What will the results tell us?
Many different things:
  • Can women and men tolerate a higher dose of methyl folate?
  • Can they follow the dietary recommendations set out at the beginning of the trial
  • Did one group do better than the other?
  • Is there sufficient evidence that this would make a good larger trial?
This has important future policy implications for governments and their health departments.
What will the funding be used for?
Your donation will support this research by supplying;
● 12-month supply of multivitamins for 60 women and 60 men - THIS HAS NOW BEEN ACHIEVED
● Shipping and distributing those vitamins - CURRENTLY ASKING FOR DONATIONS TO SUPPORT THIS.
● Blood collection- we need to collect Vitamin B12, folate and other blood work each month - CURRENTLY ASKING FOR DONATIONS TO SUPPORT THIS
● Website costs and promotion of trial for recruitment
A total of $30,000 is required for this trial, in addition to the fabulous donations we have already received.
  • Thank you to Aprofol for the folate
  • Balchem for their USD $20,000 donation
  • Factors Group for their manufacturing
With 70 million people currently experiencing infertility worldwide, every dollar donation is greatly appreciated.

Donations (15)

  • Anonymous
    • $100 
    • 6 mos
  • sarah weerappah
    • $200 
    • 1 yr
  • Michael & Julia Ledowsky
    • $1,000 
    • 1 yr
  • Anonymous
    • $250 
    • 1 yr
  • Laura Collins
    • $15 
    • 1 yr


Carolyn Ledowsky
Waverton NSW

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