The EI Cure Project is a not-for-profit organisation founded in Switzerland and America, and another is soon to be finalised in the UK also. The EI Cure Project is a global collaboration between patient advocates, investors, and world-leading researchers, all with the intention of finding a cure for Epidermolytic Ichthyosis (EI) with gene-editing.

The EI Cure Project aims to raise funds for the explicit intent of providing research grants to help those affected by EI. Any donations given to the EI Cure Project will be used for pre-clinical and clinical research with the intention of finding a cure for EI.

The research we are fundraising for includes 3 phases and it is anticipated this will take 3 to 5 years per phase, for a total of 10 to 15 years to completion of our goal to make a cure available to those affected with EI:

• Phase 1: Fund 3 PhD scholarships for pre-clinical research

• Phase 2: Conduct human clinical trials

• Phase 3: Transition availability of the treatment into the clinic

The current fundraising target is to raise￡300,000 for Phase 1 which will be divided into 3 research grants:

• Scholarship 1: Develop a CRISPR-Cas9 tool-kit to find and edit the mutation anywhere within the gene

• Scholarship 2: Explore and develop the use of base-editing tools, which permit a gene-edit without double-strand breaks

• Scholarship 3: Develop an in-vivo approach which can be used for multiple families to help reduce the high cost of a cure associated with gene-editing

For subsequent phases we will continue to fundraise but our target will be much higher. To support this, and with the support of our Phase 1 proof-of-concept data, we will be able to apply for various grants from orphan disease networks, formal research groups, and pharmaceutical companies. Our estimated target for Phase 2 and 3 is￡3 to 6 million.

If you would like to learn more about EI, what it looks like, and how much it affects everyday life, please visit our website and meet some of the babies, children, and adults in the EI community that your donations would be helping. If you prefer to listen to information, please visit our podcasts page. Here you will meet the founder, learn more about why we need to raise the funds for research ourselves, and you will also get to meet our extremely talented lead researchers.

For now, thank you so much for visiting our page and for considering a donation. The sooner we reach our target, the sooner we can start our life-changing research.