Cannabis Oil Experiment Fund
The present and recent research into the medicinal benefits of cannabinoids is (in the main) funded by large pharmaceutical companies who are seeking returns on their research investment via patents. I am currently collaborating with several leading experts and organisations on developing and carrying out independent research into the medicinal benefits of cannabinoids; one such collaboration is with Professor Manuel Guzman and his department at the Complutense University of Madrid.
Professor Manuel Guzman first came to my attention with the publication of his paper: “Cannabinoids: Potential Anticancer Agents ” (2003). My interest was roused by the second line of his opening statement:
“Cannabinoids — the active components of Cannabis Sativa and their derivatives — exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?”
Since 2003, Manuel and his department have conducted considerable research into the field of cannabinoids and cancer, in my opinion they are the world leaders in this field.
There are around 200 forms of cancer and what is becoming apparent from the research in Madrid is that some cancers react differently to combinations of cannabinoids.
Dr Guillermo Velasco specialises in cannabinoids and their effects on gliomas and pancreatic cancer. I like Guillermo very much and mainly for his answer to my question, why did you choose these two particularly aggressive forms of cancer? He responded that he selected these two particular cancers mainly because they are both very, very aggressive with a high mortality rate and unlike other forms of cancer there are no effective treatments for sufferers.
I am seeking to raise €35,000 to fund an independent experiment I am designing with Professors Guillermo Velasco, Cristina Sanchez and Manuel Guzman at the Complutense University of Madrid.
The research I hope to fund in Madrid will investigate the anti-cancer properties of cannabis and individual cannabinoids, seeking to establish the most effective cannabinoid or combination of cannabinoids. We will also investigate whether whole plant extracts or individual cannabinoids are more effective at treating breast cancer and glioma cell types than individual cannabinoids.
A pressing question for me is; which is more effective as an anti-cancer agent? whole plant extracts or individual pharmaceutical grade cannabinoids (both synthetic and plant derived)? This study will hopefully answer this question.
I cannot stress enough how important this particular research is; Guillermo recently oversaw an experiment into treating glioblastomas with cannabinoids which indicated that combining THC and CBD in equal amounts was more effective than either THC or CBD alone.
Outline of proposed experiments to be included in the project:
· Objective 1. To compare the in vitro anticancer activity of whole plant extracts vs pharmaceutical cannabinoids in glioma and breast cancer cells.
· Objective 2. To compare the anticancer activity in vivo of whole plant extracts vs pharmaceutical cannabinoids in tumour xenografts generated with glioma and breast cancer cells.
· Objective 3. To investigate the mechanism of action of THC, CBD, and THC plus CBD in glioma and breast cancer cells.
We will also analyse the participation of CB1 and CB2 receptors as well as proteins in the effect of THC, CBD, and THC plus CBD in two cell types.
Possible Future studies
We expect that the results obtained from the experiments in Objective 3 will help to set the bases for the development of further studies, including those aimed at identifying the molecular mechanisms that become activated in glioma and breast cancer cells in response to treatment with different cannabinoids.
All the useful results from this study will be placed in the public domain, so please help me to make this happen.
Co-Author of The Medical Cannabis Guidebook
In the past 48 ours, everyone who donated to our study should have received an update on the progress by e-mail, please contact us if you haven't received yours and please check your 'other' folders first.
"Onwards & Upwards"
A big thank you to NORML UK who've very kindly donated €420, I love it!
This poignant message will, I'm sure touch you as much as it has us at Bud Buddies:
My name is Melanie D*******. As you will be able to see I have donated €2,200 to your project.
To briefly explain the large sum, my mother passed away from cancer in February after a long hard battle and we promised her that any funds raised after her passing would go to the right type of cancer research.
It was the thing that mattered to her the most, for our future and the rest of the human race. These funds were raised from the funeral and through a fundraiser we held at our house in order to donate to you guys!
Towards the very end of her life mum turned to the use of cannabis oil as her only means of treatment and we can honestly say we have first hand evidence of it making a difference. She was eating, sleeping and generally stronger when she was following this treatment.
Unfortunately, we did not start the treatment early enough for Mum but she made us promise her that we could keep fighting for this treatment as it is a true miracle worker and people need to see that. The answer is in front of our eyes and the push for this research to be made in order to gain the evidence we need to prove it is vital.
Thank you so much for fighting for what you believe in, you guys are awesome.
"Onwards & Upwards"
Please redouble your efforts and let's make this happen
Here's a reminder of what Professor Guillermo Velasco from Madrid Complutense University said:
""We are really really thankful to all the generous people who have donated their money to fund this research. We feel honoured to be the recipients of this donation and at the same time feel a great responsibility. We will use every single euro in pushing forward our research on the anticancer activity of cannabinoids".
"The research that we have developed during the past 15 years has helped to demonstrate that cannabinoids have anticancer activity by themselves and that they can also enhance the anticancer action of other anti-tumoral agents at least in animal models of cancer."
"However there are still many open questions that need to be answered in this area of research including the identification of the right combination of cannabinoids and other anticancer therapies that could be more effective in each patient an tumor type. Likewise the mechanism of cannabinoid anticancer action needs to be investigated in further detail. All these studies will contribute to pave the way to the development of clinical studies that will test the anticancer activity of cannabinoids in humans suffering cancer."
" The development of this project will be one important step forward towards the achievement of these objectives".