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I'm 28 years old and spent the last 9 years as a network administrator and have interest in business with activism at heart, but recent development in my familys health has caused me to refocus and redouble my efforts and now I am pursuing a career in medicine and dedicating the rest my life to the betterment of the field of medicine. Between my parents and grandparents my family has been stricken by Alzheimer's Dementia, stomach Cancer, Diabetes, Pneumonia,Thalassemia, and a few mental heath illnesses that I have asked to keep to keep personal as to their specificity in the event that this campaign takes off and is met with attention and success. As you all know there is not any definitive cure for some of the worst diseases that plagues our planet and when it happens to us and/or the people that we know and love it can leave us with a feeling almost as bad, the feeling of being hopeless and powerless, this feeling ate at me, day and night, wishing i could do something of anything to help. So I did what most of us do, endless hours of Internet searches and I found what I was looking for, Volunteer Distributed Computing projects by BOINC (Berkeley Open Infrastructure for Network Computing).
Here is a snippet of there welcome page
"Welcome to the Rosetta@home distributed computing project and thank you for joining!
You will be helping us to solve one of the longest standing problems in molecular biology: the "protein folding" problem. Proteins are the miniature machines that carry out almost all the important functions in your body. As with any machine, understanding how proteins work requires understanding what their structures are. It has been known for over 40 years that the structures of proteins are completely determined by their amino acid sequences, and we know the amino acid sequences of all proteins in the human genome thanks to the recently completed human genome project. However, until very recently, it has seemed nearly impossible to compute the structures of proteins from their amino acid sequences, and solving this problem has been something of a scientific "Holy Grail".
As you can read in the news releases and in Science magazine, we have in the past six months made significant progress and for the first time it appears
possible to compute protein structures from their sequences. Success with this would have a huge impact on our understanding of how biology works, and
even more importantly, could lead to new therapies and vaccines to help cure disease. The major stumbling block is the very large amount of computing time
required to solve the problem.
Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major
human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we
couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, malaria, Cancer, and Alzheimer's Please join us in our efforts! Rosetta@home is not for profit."
That's just 1 of the 4 projects I'm participating in of the total of 9 medicine and biology projects (I don't have enough power for the other 5) BOINC has more
than 3 dozen active distributed computing projects in all areas of scientifical research including but not limited to Astrophysics, Aerospace, Art, Climate
study, Chemistry, Cryptography, Data analysis, Engineering, Genetics and my main focus Medicine and Biology.
The BOINC project started in February 2002 since then there are currently 3,273,214 users in 258 different countries, and as great as that sounds sadly it isnot being used to it full potential. Most of the users are not doing as much as they could be, this is where and why my campaign comes into play, my aim is to raise awareness and computational power by several orders of magnitude. Every work unit you complete gives you a credit rating to keep track of your contribution I have only been donating my computational power for less than 2 weeks now and by doubling the default CPU usage from 40% to 85% I have been able to produced more work in total, than 82.9% of all users in all projects of all time, I'm producing more recent average credit than 99.46% of all users with 5 laptops 3 years old each and 1 smart phone. Those are some high percents for 13 days of work in a 13 year old community, so this has caused me to design an extremely high powered sever I want to build. What I have accomplished so far I have done on 12 [email redacted]z, the server will have 5 racks of 120 cores(10x more) @3.6Ghz (2.25x faster) it will be 113 time more efficient being able to produce more data then I have done in 13 days in less than 3 hours! and this is just at 85%, since this is a dedicated sever with no input or usage from me it can be set as high as 98%(it needs a little room to breath) this would just be the first phase of development I plan to double in power or more if I can every year until an entire building as picured above is dedicated to this medical research power by green energies such as wind and solar power with a mural dedicated to my family and all familes that have ever had to endure any health afflictions. I would like to see this idea catch on until there's a medical research district in every major city they way there are financial districts entertainment districts and fashion districts, then it will only be a matter of time before we have answers to our most pressing of questions. By assigning high powered severs with supercomputer like processing abilities to help progress the development of vaccines, treatments, early detection and possibly even cures, we can put the power back into the people and hope where there was none or vary little.
here are Some of the disease and problems being researched by some of the projects
Rosetta@Home - By the University of Washington
Alzheimer's disease - "Alzheimer's and many other diseases are likely to be caused by abberant protein folding in which proteins form large aggregated structures called amyloids rather than folding up into their normal biologically active states. A big advance was made recently by David Eisenberg's research group at UCLA in solving the first structure of an amyloid. We are collaborating with their research group to use the structure to predict which parts of proteins are likely to form amyloids, which will be a first step to blocking amyloid formation and hopefully disease."
Prostate Cancer - "The current treatment for prostate cancer, called "hormone therapy", involves lowering the amount of testosterone available (sometimes by castration). Many malignant tumors are resistant to this therapy, however, so we are applying our protein design methodology to find different ways to inhibit the AR and to treat prostate cancer. Specifically, we are trying to design proteins that will disable the AR even in the presence of testosterone."
Cancer - "We are developing methods for cutting DNA at specific sites in the genome, and we will be targeting sites that are implicated in cancer. After these sites are cut, they should be repaired by the cell using a second, unmated copy of the gene and the cell should no longer be cancerous. This is a very specific form of gene therapy that, if successful, will circumvent one the main objections to current gene therapy methods; namely, current methods insert theunmutated copy of a gene randomly into the genome, and if the insertion point happens to be near an oncogene,the gene therapy will cure one disease but cause another. Because our methods will target specific sites instead ofrandom sites, they should avoid this pitfall."
Malaria - "The idea behind the project is to make mosquitoes resistant to the parasite by eliminating genes required in the mosquito for the parasite to live. Our part of the project is to use our computer based design methods (ROSETTA) to engineer new enzymes that will specifically target and inactivate these genes."
Anthrax - "We are using ROSETTA to help John Collier's research group at Harvard build models of anthrax toxin that should contribute to the development of treatments."
HIV - "One of the reasons that HIV is such a deadly virus is that it has evolved to trick the immune system. We are collaborating with researchers in Seattle and at the NIH to try to develop a vaccine for HIV."
Other viruses: - "We have been collaborating with Pam Bjorkman's laboratory at Cal Tech to use the ROSETTA protein-protein docking methodology to build models of herpes simplex virus proteins in complex with human proteins."
World Community Grid - By IBM and works with various institutes and universities around the world
FightAIDS@Home - "The Human Immunodeficiency Virus. The virus has affected the lives of men, women and children all over the world. Currently, there is no cure in sight, only treatment with a variety of drugs."
Outsmart Ebola Together - "Currently, there are no approved treatments or vaccines for this deadly disease, and the search for an effective antiviral drug to treat the disease is a high priority."
Mapping Cancer Markers - "The pattern of markers can determine whether an individual is susceptible to developing a specific form of Princess Margaret Cancer Centre cancer, and may also predict the progression of the disease, helping to suggest the best treatment for a given individual. These include tissues with lung, ovarian, prostate, pancreatic and breast cancers."
Uncovering Genome Mysteries - "From the realization that the Penicillium fungus kills germs, to the discovery of bacteria that eat oil spills and the identification of aspirin in willow tree bark, a better understanding of the natural world has resulted in many improvements to human health, welfare, agriculture and industry."
The Clean Energy Project stg 2 - "About 36,000 of the compounds analyzed show potential to perform at approximately double the efficiency of most current organic solar cells in production Scientists can use this information to continue investigating the most promising candidates for use in cheaper, more efficient and more flexible solar cells."
Poem@home - By Karlsruhe Institute of Technology
Peptide 415 - "A major virulence factor in species such as E. coli Salmonella, Yersinia pestis, Pseudomonas aeruginosa, Chlamydia species"
Nek2 Proteinkinase - "A protein kinase which is involved in cell division."
The Villin Headpiece - "A 36 amino acid protein which may play a role in cell plasticity."
Anti-Cancer Peptides - "Impair the cancer-growth or spread."
eqFP611 Alanine Scan - "Identify which parts of the protein are "the stickiest" and how we could change these parts."
And much more........
Once I'm able to raise the 1st% of funding I will be deciding the name for this charitable organization and shortly after open a corresponding website with statistics on progress updated daily, also past and current accomplishments in the development of the research with atypical health tips with references
among other things
Thank you for taking the time to read this this site is truly amazing people from all over helping people from all over from minor to major from a to z, all hopes, goals, dream, and needs. there are so many talented people with world changing ideas who many not necessarily have the contacts or means to act on them we truly live in the best time to be alive with the invention and explosion of the Internet and social media for the first time in Earths history anyone has the ability to do anything.
Thank you for your time and take care.
P.S As a side note I would ask that you take a minute and look into "volunteer distributed computing projects by BOINC" idle CPU cycles can help save lives .
There is never a wrong time to do the right thing
Here is a snippet of there welcome page
"Welcome to the Rosetta@home distributed computing project and thank you for joining!
You will be helping us to solve one of the longest standing problems in molecular biology: the "protein folding" problem. Proteins are the miniature machines that carry out almost all the important functions in your body. As with any machine, understanding how proteins work requires understanding what their structures are. It has been known for over 40 years that the structures of proteins are completely determined by their amino acid sequences, and we know the amino acid sequences of all proteins in the human genome thanks to the recently completed human genome project. However, until very recently, it has seemed nearly impossible to compute the structures of proteins from their amino acid sequences, and solving this problem has been something of a scientific "Holy Grail".
As you can read in the news releases and in Science magazine, we have in the past six months made significant progress and for the first time it appears
possible to compute protein structures from their sequences. Success with this would have a huge impact on our understanding of how biology works, and
even more importantly, could lead to new therapies and vaccines to help cure disease. The major stumbling block is the very large amount of computing time
required to solve the problem.
Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major
human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we
couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, malaria, Cancer, and Alzheimer's Please join us in our efforts! Rosetta@home is not for profit."
That's just 1 of the 4 projects I'm participating in of the total of 9 medicine and biology projects (I don't have enough power for the other 5) BOINC has more
than 3 dozen active distributed computing projects in all areas of scientifical research including but not limited to Astrophysics, Aerospace, Art, Climate
study, Chemistry, Cryptography, Data analysis, Engineering, Genetics and my main focus Medicine and Biology.
The BOINC project started in February 2002 since then there are currently 3,273,214 users in 258 different countries, and as great as that sounds sadly it isnot being used to it full potential. Most of the users are not doing as much as they could be, this is where and why my campaign comes into play, my aim is to raise awareness and computational power by several orders of magnitude. Every work unit you complete gives you a credit rating to keep track of your contribution I have only been donating my computational power for less than 2 weeks now and by doubling the default CPU usage from 40% to 85% I have been able to produced more work in total, than 82.9% of all users in all projects of all time, I'm producing more recent average credit than 99.46% of all users with 5 laptops 3 years old each and 1 smart phone. Those are some high percents for 13 days of work in a 13 year old community, so this has caused me to design an extremely high powered sever I want to build. What I have accomplished so far I have done on 12 [email redacted]z, the server will have 5 racks of 120 cores(10x more) @3.6Ghz (2.25x faster) it will be 113 time more efficient being able to produce more data then I have done in 13 days in less than 3 hours! and this is just at 85%, since this is a dedicated sever with no input or usage from me it can be set as high as 98%(it needs a little room to breath) this would just be the first phase of development I plan to double in power or more if I can every year until an entire building as picured above is dedicated to this medical research power by green energies such as wind and solar power with a mural dedicated to my family and all familes that have ever had to endure any health afflictions. I would like to see this idea catch on until there's a medical research district in every major city they way there are financial districts entertainment districts and fashion districts, then it will only be a matter of time before we have answers to our most pressing of questions. By assigning high powered severs with supercomputer like processing abilities to help progress the development of vaccines, treatments, early detection and possibly even cures, we can put the power back into the people and hope where there was none or vary little.
here are Some of the disease and problems being researched by some of the projects
Rosetta@Home - By the University of Washington
Alzheimer's disease - "Alzheimer's and many other diseases are likely to be caused by abberant protein folding in which proteins form large aggregated structures called amyloids rather than folding up into their normal biologically active states. A big advance was made recently by David Eisenberg's research group at UCLA in solving the first structure of an amyloid. We are collaborating with their research group to use the structure to predict which parts of proteins are likely to form amyloids, which will be a first step to blocking amyloid formation and hopefully disease."
Prostate Cancer - "The current treatment for prostate cancer, called "hormone therapy", involves lowering the amount of testosterone available (sometimes by castration). Many malignant tumors are resistant to this therapy, however, so we are applying our protein design methodology to find different ways to inhibit the AR and to treat prostate cancer. Specifically, we are trying to design proteins that will disable the AR even in the presence of testosterone."
Cancer - "We are developing methods for cutting DNA at specific sites in the genome, and we will be targeting sites that are implicated in cancer. After these sites are cut, they should be repaired by the cell using a second, unmated copy of the gene and the cell should no longer be cancerous. This is a very specific form of gene therapy that, if successful, will circumvent one the main objections to current gene therapy methods; namely, current methods insert theunmutated copy of a gene randomly into the genome, and if the insertion point happens to be near an oncogene,the gene therapy will cure one disease but cause another. Because our methods will target specific sites instead ofrandom sites, they should avoid this pitfall."
Malaria - "The idea behind the project is to make mosquitoes resistant to the parasite by eliminating genes required in the mosquito for the parasite to live. Our part of the project is to use our computer based design methods (ROSETTA) to engineer new enzymes that will specifically target and inactivate these genes."
Anthrax - "We are using ROSETTA to help John Collier's research group at Harvard build models of anthrax toxin that should contribute to the development of treatments."
HIV - "One of the reasons that HIV is such a deadly virus is that it has evolved to trick the immune system. We are collaborating with researchers in Seattle and at the NIH to try to develop a vaccine for HIV."
Other viruses: - "We have been collaborating with Pam Bjorkman's laboratory at Cal Tech to use the ROSETTA protein-protein docking methodology to build models of herpes simplex virus proteins in complex with human proteins."
World Community Grid - By IBM and works with various institutes and universities around the world
FightAIDS@Home - "The Human Immunodeficiency Virus. The virus has affected the lives of men, women and children all over the world. Currently, there is no cure in sight, only treatment with a variety of drugs."
Outsmart Ebola Together - "Currently, there are no approved treatments or vaccines for this deadly disease, and the search for an effective antiviral drug to treat the disease is a high priority."
Mapping Cancer Markers - "The pattern of markers can determine whether an individual is susceptible to developing a specific form of Princess Margaret Cancer Centre cancer, and may also predict the progression of the disease, helping to suggest the best treatment for a given individual. These include tissues with lung, ovarian, prostate, pancreatic and breast cancers."
Uncovering Genome Mysteries - "From the realization that the Penicillium fungus kills germs, to the discovery of bacteria that eat oil spills and the identification of aspirin in willow tree bark, a better understanding of the natural world has resulted in many improvements to human health, welfare, agriculture and industry."
The Clean Energy Project stg 2 - "About 36,000 of the compounds analyzed show potential to perform at approximately double the efficiency of most current organic solar cells in production Scientists can use this information to continue investigating the most promising candidates for use in cheaper, more efficient and more flexible solar cells."
Poem@home - By Karlsruhe Institute of Technology
Peptide 415 - "A major virulence factor in species such as E. coli Salmonella, Yersinia pestis, Pseudomonas aeruginosa, Chlamydia species"
Nek2 Proteinkinase - "A protein kinase which is involved in cell division."
The Villin Headpiece - "A 36 amino acid protein which may play a role in cell plasticity."
Anti-Cancer Peptides - "Impair the cancer-growth or spread."
eqFP611 Alanine Scan - "Identify which parts of the protein are "the stickiest" and how we could change these parts."
And much more........
Once I'm able to raise the 1st% of funding I will be deciding the name for this charitable organization and shortly after open a corresponding website with statistics on progress updated daily, also past and current accomplishments in the development of the research with atypical health tips with references
among other things
Thank you for taking the time to read this this site is truly amazing people from all over helping people from all over from minor to major from a to z, all hopes, goals, dream, and needs. there are so many talented people with world changing ideas who many not necessarily have the contacts or means to act on them we truly live in the best time to be alive with the invention and explosion of the Internet and social media for the first time in Earths history anyone has the ability to do anything.
Thank you for your time and take care.
P.S As a side note I would ask that you take a minute and look into "volunteer distributed computing projects by BOINC" idle CPU cycles can help save lives .
There is never a wrong time to do the right thing