Support Lampidis 2-DG Cancer Trial

$2,205 of $75,000 goal

Raised by 33 people in 45 months
Professor of Cell Biology at the University of Miami Miller School of Medicine, Dr Theodore Lampidis could just be sitting on one of the holy grails of medicine – a universal treatment for all types of cancer.

Dr. Lampidis has published more than 100 research papers in respected scientific journals, but it is his latest review article, The Wonders of 2-DG, which is causing a stir in the scientific community and receiving rave reviews from his peers around the world. It is a distillation of his life's work into glucose metabolism and its effect on cancerous tumors.

There is an elegant simplicity to Dr. Lampidis’ groundbreaking research which has universal appeal. He is a pioneer in exploring and exploiting the unique usage of glucose in cancer cells using a simple sugar compound called 2-Deoxyglucose (2-DG). His discovery is based on the fact that the cancer cells most resistant to chemotherapy found within the inner core of all solid tumors do not receive enough oxygen (a state known as hypoxia) and therefore must rely exclusively on sugar to survive.

Dr. Lampidis hypothesized he could target these hypoxic tumor cells by feeding them 2-DG and effectively starve them to death. The process of breaking down glucose (glycolysis) is so fundamental, it has survived a billion years of evolution dating back to a time when there was no oxygen in our atmosphere and the only source of energy that could be used to keep tiny microbes alive was sugar.

Dr. Lampidis' eureka moment led to two consecutive five-year awards from the National Cancer Institute, which stated in the reviews of his research that “Dr. Lampidis’ work could eventually lead to cures in certain cancers.”

This led to an FDA-approved Phase I clinical trial to determine the tolerable dose level of 2-DG. The results of the trial (which have recently been published) sets the groundwork for the next Phase II clinical trial, which requires investigating the most effective combination treatments and drug delivery methods.

And that’s where he has hit a roadblock. The unfortunate reality is that since 2-DG cannot be patented, pharmaceutical companies are not interested in devoting their resources to bring this wonder drug to market.

Although the University has been very supportive of his work, resources are limited due to budget cuts and reductions in federal funding from the National Institutes of Health, and from a team of five post graduate researchers in his lab he finds himself left with just one technician.
 
A dedicated group of volunteers have banded together to raise awareness and funding for Dr Lampidis’ groundbreaking work. And we’re calling on the GoFundMe community to help raise funds for Phase II clinical trials for 2-DG and bring this revolutionary treatment to benefit cancer sufferers world-wide. We are convinced that if 2-DG could be patented, this drug would already be available to cancer sufferers everywhere.

Please join our cause and help us fight the fight in bringing this universal treatment to cancer patients suffering from this devastating disease. For further information visit: www.lampidisfoundation.org .
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It’s really very simple. The high rate of mutation giving rise to too many different types of cancer cells in a growing tumor has made it nearly impossible for so-called “tailored” or “targeted” therapy to succeed. Billions of dollars have been spent so far using this approach with modest to little benefit to most cancer patients treated.

So why not come up with a new strategy that is based on a more rational approach?

For more than 30 years the results from literally millions of PET scans has shown us that tumors take up more glucose than normal surrounding tissues. But only more recently has the reason for this increased glucose uptake in tumors become known.

Surprisingly, or perhaps not so surprisingly when one thinks about it, the same genes that are driving cancer (oncogenes) have been found to be responsible for directing a cancer cell to take up more glucose.

Using sophisticated techniques such as NMR and Mass Spec it has been shown that the glucose molecule is not only a vital energy source but provides the building blocks required for a cell to replicate.

Thus, increased glucose metabolism is the universal trait that investigators have long been seeking in their quest to find a feature common to all cancer cells regardless of their tissue origin or genetic (oncogene) profile.

Our approach, therefore, using the analog of glucose, 2-deoxy-D-glucose , better known as 2-DG, takes advantage of this natural window of selectivity that increased glucose uptake provides in cancer vs. normal cells.

We have provided proof of principle that 2-DG works in many different tumor cell types when grown in the lab in vitro (in dishes) and have advanced our ideas in vivo (in tumor animal models). Our results have taken 2-DG all the way up to and including completion of an FDA-approved Phase I human clinical trial.

So why isn’t this universal treatment for cancer not already helping cancer patients suffering from this devastating disease world-wide?

There are many answers to that question, but the major obstacle that has slowed the development of 2-DG is that it is not patentable.

Therefore, the pharmaceutical industry is not interested in providing the financial resources required to put it through the next phase of clinical trials needed to make 2-DG a frontline treatment.

Other obstacles, less obvious but perhaps equally important, preventing 2-DG from reaching patients are the unwillingness of those in control of funds to devote the resources to treatments that they are either not part of or, for personal or political reasons, are against.

Although our lab and this work has attracted and been awarded National Institutes of Health Grants for more than 20 years, the funding from these sources is dwindling and we have therefore turned to philanthropy to get us to the next step.

So please take a moment to visit our website at www.lampidisfoundation.org to learn more about our work and to see why we ask you to join us in helping bring this universal treatment to benefit cancer patients world-wide.
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Lorena Rojas, 44, Actress, Patron, Friend, Loses Her Battle with Cancer

It is with great sadness that we report the passing of our dear friend Lorena Rojas, who succumbed to her seven-year battle with cancer at the young age of 44. She was a wonderfully talented actress, musician and patron of the arts who graciously supported the Lampidis Cancer Foundation. Her perseverance and dedication in the face of such overwhelming odds made her an inspirational role model to many. It is a great frustration for us at the Foundation that we could not do more to help Lorena recover from her devastating illness. We all owe it to the courageous way she lived to redouble our efforts in bringing our universal cure for cancer to help other sufferers of this deadly disease. We believe that the lives of so many could at the very least be prolonged, if not saved, if only we could overcome the financial hurdles and bring 2-DG to benefit patients worldwide.

Our thoughts are with Lorena’s family at this difficult time, including her boyfriend, Jorge, and beautiful daughter Luciana.


Lorena Rojas 1971-2015
Lorena Rojas was a popular Mexican actress who starred in more than a dozen soap operas. Born in Mexico City, Mexico in 1971, she earned her first acting credits in the early 1990s. Lorena starred in such acclaimed Spanish soaps (known as telenovelas) as El Cuerpo del Deseo, Pecados Ajenos, Alcanzar Una Estrella and, most recently, the series Demente Criminal. She also appeared in films such as Manos Quietas and Aventurera.

In addition, the actress recently wrote and recorded an album of children's music called Hijos del Sol, which was inspired by her daughter Luciana.

She was diagnosed with breast cancer in 2008 and became an advocate for cancer education in Latino communities. She was a dear friend and supporter of the Lampidis Cancer Foundation since its establishment in 2013. She will be greatly missed, but her spirit and inspiration will forever be guiding us.
Lorena Rojas, 1971-2015
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Many thanks to those of you who have contributed to help bringing our universal treatment for cancer patients world-wide once step closer to reality. Although we have come a long way from concept, to testing in laboratory dishes, to animal studies, and have now successfully completed a human Phase I clinical trial, we need your help to keep us going as we can no longer rely on the dwindling sources from NIH grants. We've learned a lot from these studies and are extremely encouraged by our latest results which show that a new way to deliver 2-DG in combination with a non-toxic non-cancer chemotherapeutic drug, significantly inhibits the growth of human tumors in animals. We are optimiizing this treatment and need more in vitro and in vivo studies to determine how universal our effects are. Our preliminary results indicate that this combination and delivery system will work in a variety of cancers.

Now that you have become advocates of our cause we kindly ask for you to become disciples by sending our gofundme link to your relatives, friends and associates and asking them to do the same. If each of them contacts at least 3 or 4 individuals and they in turn continue doing that, I am confident we will raise enough funds to reach our goal of using 2-DG to ease the suffering of the tens of millions of patients and their families who are affected by this devastating disease.
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$2,205 of $75,000 goal

Raised by 33 people in 45 months
Created October 28, 2014
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MH
$100
Michael Hayley
36 months ago

In memory of Jesse Hayley and Juanita Hayley

AF
$20
Alexandra Ferguson
41 months ago

Thank you!!!

$50
Anonymous
41 months ago
$20
Anonymous
41 months ago
VO
$100
Victor Okoh
41 months ago

Please don't give up the fight, breakthrough may be just around the corner.

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