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In 2018 Kaleb lost his Dad; Johnnie Pittman to an aggressive form of Colon Cancer.
Kaleb has been diagnosed with Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called hereditary flat adenoma syndrome[1]) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself is the most severe and most common; although for all three, the resulting colonic polyps and cancers are confined to the colon wall and removal can greatly reduce the spread of cancer.
The root cause of FAP is understood to be a genetic mutation—a flaw in the body's tumor suppressor genes that prevent development of tumors. The flaw allows numerous cells of the intestinal wall to develop into potentially cancerous polyps when they would usually reach the end of their life; inevitably one or more will eventually progress and give rise to cancer (7% risk by age 21, rising to 87% by age 45 and 93% by age 50). The flawed genes do not trigger cancer, but rather, they reduce the body's ability to protect against the risk of aged cells becoming cancerous. Even with the flawed gene, it may still take time before a cell does develop that is cancerous as a result, and the gene may in some cases still partially operate to control tumors, therefore cancer from FAP takes many years to develop and is almost always an adult-onset disease.
Kaleb will most certainly have to have his colon removed by the age of 15. We are setting up this page to help him with the medical costs to come.
Kaleb has been diagnosed with Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called hereditary flat adenoma syndrome[1]) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself is the most severe and most common; although for all three, the resulting colonic polyps and cancers are confined to the colon wall and removal can greatly reduce the spread of cancer.
The root cause of FAP is understood to be a genetic mutation—a flaw in the body's tumor suppressor genes that prevent development of tumors. The flaw allows numerous cells of the intestinal wall to develop into potentially cancerous polyps when they would usually reach the end of their life; inevitably one or more will eventually progress and give rise to cancer (7% risk by age 21, rising to 87% by age 45 and 93% by age 50). The flawed genes do not trigger cancer, but rather, they reduce the body's ability to protect against the risk of aged cells becoming cancerous. Even with the flawed gene, it may still take time before a cell does develop that is cancerous as a result, and the gene may in some cases still partially operate to control tumors, therefore cancer from FAP takes many years to develop and is almost always an adult-onset disease.
Kaleb will most certainly have to have his colon removed by the age of 15. We are setting up this page to help him with the medical costs to come.
Organizer
Kirk Walker
Organizer
Scottsville, NY
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