Acute promyelocytic leukemia (APML, APL) is a subtype of acute myeloid leukemia (AML), a cancerof the white blood cells. In APL, there is an abnormal accumulation of immature granulocytescalled promyelocytes. The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARα or RARA) gene and is distinguished from other forms of AML by its responsiveness to all-trans retinoic acid (ATRA; also known as tretinoin) therapy.
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