<div>Valentina, our gorgeous baby daughter, will be two in May. In November last year, we learned that she likely had Rett syndrome: after months of concerning signs in her development, followed by more worryingly skill regression, a loss of interest in toys and almost impossible to control hand mouthing. Genetic testing confirmed the diagnosis just before Christmas, a 1 in 10,000 chances of “winning” the worst lottery ever.
</div>
<div><strong>Rett syndrome is a rare, severe neurodevelopmental disorder that affects mostly girls.</strong> As we began to learn more, we discovered a devastating reality: most children and adults with Rett are unable to speak, walk or use their hands. Breathing difficulties, seizures, feeding tubes, anxiety, gastrointestinal and orthopaedic complications are common. Most people with Rett syndrome are severely disabled and <strong>will need round the clock care for life</strong>.
</div>
<div>You don’t truly understand grief until you hear something like this about your daughter. The place we found ourselves in was dark – filled with sadness, uncertainty and fear. And yet, through it all, Valentina never lost her smile. Her bright, unwavering joy became our anchor and, with the support of our family and friends, eventually brought us back to life.
</div>
<div>Her smile gave us the courage to learn everything we could about Rett, so we could do our very best to support our little angel. Through that learning, <strong>we discovered </strong><a href="https://www.reverserett.org.uk/" target="_blank" rel="noreferrer noopener"><strong>Reverse Rett</strong></a><strong> and the extraordinary and inspiring work they support</strong> to advance genetic medicines that target the root cause of Rett – most often a mutation on a gene called MECP2 on the X chromosome. For the first time, we encountered real hope: two gene therapy programmes now in the final stage of clinical trials.
</div>
<div>Beyond the science, <strong>Reverse Rett supported us as a family when we needed it most</strong>. Andy and the team were there whenever we needed to talk, offering reassurance, guidance and hope. They provided a much needed sense of community when we felt so isolated, and they connected us with other families walking the same path.
</div>
<div>A large part of the strength we have today is thanks to Reverse Rett – and to the hope they helped us find. Hope that Valentina may one day tell us she loves us. Hope that she might walk while holding our hands. Hope that she will not be trapped inside her own body.
</div>
<div>We are now on a mission: <strong>to raise funds so Reverse Rett can continue their vital work</strong> – not just for Valentina and all the diagnosed girls in the UK, but for every family who will receive this diagnosis in the future. Throughout 2026, we will craft, run, sing, walk and write – including developing a fantasy story with Valentina as its hero – to raise funds, awareness and, above all, hope.
</div>
<div>Help us make a difference for Valentina, and for every girl diagnosed with Rett syndrome. The science is ready, the momentum is real, the time to act is now. A world where Rett no longer means lifelong suffering is closer than ever – and by acting now, <strong>we can help accelerate the progress that families like ours cannot afford to wait for.</strong>
</div>

Anonymous

Neil Forrester

Mara Shepherd

A V Sharp

Susana Torres Arenas

Paul Doyle

Oa The Fastitocalon

Susana Garcia

Luz Marina Rendón Escobar

javier lopez martinez

Esther Esteban

Nancy MacDonald

Klaudiusz Ciesielski

Raising Our Voice for Valentina: for everyone with Rett

platform

Platform is iOS

Android

Adyen Google Pay Development Audience

$opt_dummy_attribute

English only

Deprecate Stripe Legacy

dyn_template_ids

Adyen V6 Bene Transfer & MyMoney Campaign Organizers - test01

Bene transfer V6 and AdyenV6MyMoney Campaign Organizers - production

OneTrust next-app audience

fundCountryCode

NextDoor Share Option Users

Fundraisers with Reactions feature capability

fundCurrencyCode

US + Non-charity COs Only

locale

fund country is US and user language is English

personId

comms-internal-person-ids

Enhanced Story Experience Users

Suggested Goal Experience Users

user language is English and fund country: US, AU, DK, FI, IE, NO, SE, CA, GB; 

Poster share - new funds eligible (newest 9/18)

Streaming widgets beta user

paymentProcessor

3DS payment method

user language is English and fundCountry: US, AU, DK, FI, IE, NO, SE, CA, GB; 

GoFundMe Employees

ipAddress

Mark Rieth IP Address

Version 9.2.0 and above

Fund is in English speaking country

desktop

Android v12.11.0 and above

Platform is Android

paymentMethodType

checkoutType

Payment method type group to be vaulted on success

admin pr kit prod

EUR Donation Upsell

Share Text generation Skip Fundraiser

(prod) new funds eligible for amp12 (UGC gallery)

fintrac_cad_idv_form_v2 audience

paymentProcessorAccountId

fallback mode accounts

proCampaignId

p2p legacy startfundraising page

AMP24 New Funds Only PROD (DO NOT MODIFY)

countryCode

charityId

UKCharities

Federated Search Internal Testing

route.pathname community

US Donation Upsell audience 

Auto Thanks Feature Audience

Supporter Comments Eligible Funds

International Only

fundId

braze fundraiser group 

Payment Identity Transfers ATO Risk Check (Targeted) - Production

Fundraiser Saved Payment Method Rate Limit Bypass (Production)

leaderboard-partner-id-audience-givepanel

Version 9.2.1 and above

AUD Donation Upsell audience

fundraiserCountryCode is US/EN

Active Fundraiser - Smart Default Cadence

DAF Internal

Vault on success card payment method

Platform is iOS v11.0.0 and above

Desktop users

Person ids

United States (US) users

allow yuno fundraisers for test

Mexico country code

Posters INTL

NPO Profile Opted-In

iOS at or above 12.4.0

non-US recurring donors

Canada Campaign Owner Group

Fundraiser Without Meta Link

Scheduler payment tester gorup

charityCommunityId

Charities allow to be claimed unclaimed (PRD)

Canada (CA) users

currencyCode

UC Tipping v20250115 International

pymk_production_xplr_fe_team

Android at or above 12.2.0

Profile photo entry point audience

smart goals (fundraiser/manage) on test01

Activity Tracking v1 Beta Testing

writePath

Stream Notification

start gfm intl allowed locales

Platform is iOS v11.2.0 and above

unclaimed charities

prod_ach_audience

AI Chatbot Audience

amp13 only new funds (prod) (anyword auto)

UC Flow Enabled (Prod)

Payment Identity Beneficiary Verification - Production

shared notification bell audience

Custom users

ach frontend audience

Android v11.0.0 and above

Users Receiving Payments Paused Notifications

smart goals test01

Manage Coach - US English Organizers Only + new funds only

Team EGG - IP Address list

Fundraiser Without Instagram Deep Link

Native 11.4.0 and above

UC Tipping v20250107

Users Receiving Braze KYC Validation Failed

Native 11.3.0 and above

Influencer - Prod

US fundraisers and US users

ai_title_page

anyword

openai

control

manual_entry

userEmail

template_id

userId

fundUrl

isCharityCo

email

appVersion

shouldBucketIntoExperiment

partnerId

donationCadence

isActiveFundraiser

isPartner

isMobile

npoProfileOptIn

fundIsLinkedWithMeta

hasSessionDonation

isCampaignOwner

fundHasInstagramDeepLink

Native 11.4.0 and higher

New funds eligible - Video Sharing (PROD)

GB Donation Upsell audience 

Auto Thanks V3 Rollout Audience

Thank you V3 testing whitelist

isRecurringFriendly

Is Recurring Friendly

Excluded funds - Video Sharing

Logged In Users

CH Donation Upsell audience

Android v10.6.0 and above

userCurrencyCode

Localized Currency

v11.5.0 and above

testAudience

pathname

Survicate

appVersion is at or above 12.8.0

Non-charity fund

isChallengeFundraiser

challenge-fundraisers

Payment Identity Launch Verification - Production

New funds eligible - Posters v2

CAD Donation Upsell Audience

Braze Email Tester

NPO Profile Opted-Out

iOS App Version

hasKnownDonors

PYMK has donors

iOS v12.3.0 and above

Raising Our Voice for Valentina: for everyone with Rett

Still £1,695 to go. Help us build momentum.