<div>Meet Archer
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<div>Our beautiful little boy, Archer, is nearly 3 years old.
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<div>If you met him, you’d first notice his huge smile, infectious laugh and the way he lights up a room. He loves making people laugh, cuddles with his family, and works incredibly hard every single day to learn new skills that many children take for granted.
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<div>But behind that cheeky smile is a very rare genetic condition called CNOT3-related disorder.
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<div>After years of appointments, therapies, scans and genetic testing, we finally received an answer. Archer has a change in his CNOT3 gene—a condition so rare that very little is known about it.
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<div>For our family, finally having a diagnosis brought relief, but it also brought a heartbreaking reality…
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<div>There is currently no treatment.
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<div>How CNOT3 affects Archer
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<div>CNOT3-related disorder affects every child differently, but for Archer it has already meant significant developmental challenges.
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<div>He has developmental delays affecting his movement and speech and has needed support from physiotherapists, speech and language therapists, Portage, hospital specialists and genetic experts from a very young age.
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<div>Things many families experience naturally—first words, climbing stairs, running, jumping or speaking in sentences—have taken Archer enormous determination and countless hours of therapy.
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<div>Despite everything he faces, Archer continues to amaze us every day. Every new word, every new skill and every milestone feels like a huge victory.
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<div>He is the happiest, funniest and most loving little boy, and we want to give him—and every child diagnosed after him—the greatest chance possible.
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<div>Why we’re fundraising
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<div>The University of Sheffield, together with Archer’s clinical geneticist, has developed a dedicated research programme focused on CNOT3-related disorder.
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<div>This research aims to better understand the condition and investigate ways of restoring normal CNOT3 protein levels, an essential first step towards developing future gene therapies.
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<div>The University believes this work could help pave the way towards treatments for children affected by CNOT3-related disorder.
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<div>To begin this research, they need to raise £70,000.
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<div>This funding would support a research technician and laboratory costs for one year, allowing scientists to:
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<div>* deepen understanding of how CNOT3-related disorder affects the body
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<div>* investigate ways to restore CNOT3 protein levels
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<div>* lay the foundations for future gene therapy research
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<div>If successful, this work could lead to a larger three-year research programme aimed at developing proof-of-concept gene therapy.
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<div>For families like ours, this represents something we’ve never had before…
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<div>Hope.
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<div>Why this matters
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<div>Rare diseases often receive very little research funding simply because so few people are affected.
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<div>Children like Archer deserve the same hope as children with more common conditions.
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<div>Every donation, no matter how small, helps move this research one step closer to becoming reality.
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<div>Even if a treatment doesn’t come in time to change Archer’s future completely, we hope that one day another family receiving this diagnosis will be told there is something doctors can do.
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<div>That would mean everything.
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<div>How you can help
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<div>Whether you donate £5 or simply share our page with others, you are helping to start something that has never existed before—dedicated research into CNOT3-related disorder.
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<div>From the bottom of our hearts,
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<div>Thank you for believing in Archer and every child living with this incredibly rare condition.
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<div>❤️ Ellis, Toby &amp; Archer 
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Anna Hardisty

Alan Clithero

craig broomfield

Lea Broomfield

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Help start the Worlds first CNOT-3 research programme

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